A-Level Biology AQA Notes

3.1.4.1 General properties of proteins

General properties of proteins
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Proteins
  • Amino acids are the monomer units used to make proteins.
  • The 20 naturally occurring amino acids only differ in their R groups
Picture
  • Dipeptides are formed when two amino acids are joined together by a condensation reaction, forming a peptide bond.
  • A polypeptide is a polymer made of many amino acids joined together by peptide bonds.
  • A protein may contain one or more polypeptide chains.
Level
Definition
Solubility in Water
Primary
​The specific sequence of amino acids in a polypeptide chain
​​Peptide Bonds
Secondary
​The curling or folding of the polypeptide chain into α-helices and β-pleated sheets due to the formation of hydrogen bonds
Hydrogen Bonds
Tertiary
The overall specific 3-D shape of a protein, which is determined by interactions between R groups and the properties of R groups
​Hydrogen bonds

​Ionic bonds

Disulphide bridges
Quaternary
​The specific 3-D shape of a protein that is determined by the multiple polypeptide chains and/or prosthetic groups bonded together
​Hydrogen bonds

​Ionic bonds

Disulphide bridges

​Biochemical tests
Molecule
Reagent
Positive result
Reducing sugars
Benedict’s reagent → Heat
​Red/orange precipitate
Non-reducing sugars
Hydrochloric acid → Heat
Sodium hydrogencarbonate

Benedict’s reagent → Heat
Red/orange precipitate
Starch
Iodine in potassium iodide solution
Blue/black
Proteins
Sodium hydroxide

Copper (II) sulphate
Purple
Lipids
​Ethanol

Water → Shake
Cloudy white

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General properties of proteins
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