A-Level Biology AQA Notes

3.6.4.1 Principles of homeostasis and negative feedback

Communication Systems
  • The neuronal system uses neurones to carry signals very rapidly through the body to produce short-term responses
  • The hormonal system uses blood to carry hormones from endocrine glands to target cell with the specific receptors. This usually produces long-term responses.
    • Peptide hormones are made of amino acids and must bind to receptors on the cell surface, activating second messengers which control transcription.
    • Steroid hormones are formed from lipids and soluble in the plasma membrane, therefore entering cells and binding to proteins to enter the nucleus and have an effect on the DNA.

​Homeostasis
  • Homeostasis is the maintenance of a constant internal environment despite internal or external changes.
  • Temperature & pH are important to regulate to allow optimum enzyme activity and rate of metabolic reactions.
  • Water potential is important to regulate to prevent cells bursting or shrinking.
  • Glucose concentration is important to regulate to allow cells to have access to the substrate for respiration, whilst preventing cell damage by dehydration caused by high concentrations.
  • Negative feedback is the body’s mechanism for reversing a change so that it returns back to the optimum. The stages involve
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  • Positive feedback is a deviation from the optimum which causes changes resulting in an even greater deviation from the norm. This is usually harmful due to the large, unstable change in the body.